Precodil 5 mg is a synthetic corticosteroid with glucocorticoid properties. It inhibits the enzyme phospholipase A2, preventing the production of inflammatory mediators like leukotrienes, SRS-A, and prostaglandins. It is rapidly absorbed from the gastrointestinal tract, with 70-90% plasma protein binding and a half-life of 2–4 hours. It is metabolized in the liver and excreted in urine.
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Rheumatic Disorders: Used for managing conditions such as psoriatic arthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute and subacute bursitis, acute nonspecific tenosynovitis, acute gouty arthritis, and post-traumatic osteoarthritis.
Endocrine Disorders: Effective for primary or secondary adrenocortical insufficiency, congenital adrenal hyperplasia, nonsuppurative thyroiditis, and hypercalcemia associated with cancer.
Dermatologic Conditions: Treats severe skin disorders like pemphigus, bullous dermatitis herpetiformis, severe erythema multiforme, exfoliative dermatitis, mycosis fungoides, and severe psoriasis.
Allergic Conditions: Relieve seasonal or perennial allergic rhinitis, bronchial asthma, contact dermatitis, atopic dermatitis, serum sickness, and drug hypersensitivity reactions.
Respiratory Disorders: Used for conditions such as symptomatic sarcoidosis, berylliosis, fulminating aspiration pneumonitis, and severe lung infections.
Hematologic Disorders: Manages idiopathic thrombocytopenic purpura, secondary thrombocytopenia, acquired autoimmune hemolytic anemia, erythroblastopenia, and RBC anemia.
Edematous States: Induces diuresis and remission of proteinuria in nephrotic syndrome without uremia, including cases caused by lupus erythematosus.
Gastrointestinal Diseases: Effective for managing ulcerative colitis and regional enteritis.
Treatment of Allergic reactions/conditions
Initial Dose: Ranges between 5 mg and 60 mg daily, depending on the condition. After a favorable response, the dose should be gradually reduced to the lowest effective maintenance dose. Abrupt withdrawal should be avoided, especially after long-term use.
Multiple Sclerosis: 200 mg daily for one week, followed by 80 mg every other month.
Adult-Nephrotic Syndrome:
Common: Increased appetite, indigestion, restlessness, or nervousness.
Less Common/Rare: Changes in skin color, dizziness, facial flushing, hiccups, excessive sweating, and spinning sensations.
Prolonged use of high doses can lead to adverse effects. Gradual dose reduction is recommended for treatment. Overdose should be managed symptomatically.
Precodil 5 mg's effectiveness may be reduced by drugs such as aminoglutethimide, antacids, barbiturates, carbamazepine, griseofulvin, mitotane, phenylbutazone, phenytoin, primidone, and rifampin. It can lower potassium levels, increasing the risk of cardiac arrhythmias if combined with digitalis. Caution is advised during immunizations.
Precodil 5 mg should not be used in patients with systemic infections unless specific anti-infective therapy is initiated. It is also contraindicated in individuals allergic to its ingredients and those with ocular herpes simplex due to the risk of corneal perforation.
Corticosteroids like Precodil 5 mg should be used in pregnancy and breastfeeding only if the potential benefits outweigh the risks. Infants born to mothers who used corticosteroids during pregnancy should be monitored for signs of hypoadrenalism. Salt restriction and potassium supplementation may be necessary.
Use caution in patients with diabetes, hypertension, psychological disorders, osteoporosis, chronic nephritis, and postmenopausal women. Long-term use can lead to conditions such as Cushing’s habitus, hyperglycemia, muscle weakness, delayed wound healing, psychiatric disturbances, and increased susceptibility to infections.
Store Precodil 5mg in a cool, dry place, away from light. Keep it out of reach of children.
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.